Seroprevalence of influenza A (H9N2) virus infection among humans in
China: A meta-analysis
Abstract
In order to fully evaluate the seroprevalence and risk factor of avian
influenza A (H9N2) virus infection among humans in China, a systematic
review and meta-analysis was performed. The literature on the
seroprevalence of human H9N2 infection in China was searched from
inception to March 20, 2020 in English and Chinese databases, including
PubMed, Clinical Trial, VIP, CNKI and databases. Duplicated literature,
and literature with incomplete data were excluded, leaving the results
from 41 studies on H9N2 infection among humans in China being analyzed
quantitatively by meta-analysis. A total of 41 studies (including data
of 47,743 humans) met the inclusion criteria. In China, the overall
seroprevalence of H9N2 infection among humans was 4.10% (95%CI=
3.20-5.07), while in those from north China the prevalence was 5.94%
(95%CI= 4.75-7.13), greater than in other regions of China. The
seroprevalence of H9N2 infections was associated with test method,
sampling time, gender and demographic characteristics of the groups.
This review clearly indicates that the risk factors for H9N2 infection
varies with multiple factors. Thus, further research is needed on how to
formulate specific measures to minimize the emergence and transmission
of influenza virus.