Potential COVID-19 Effects on Reproductive Systems and Fertility; ART
Guidelines and Considerations: A Review
Abstract
The novel coronavirus SARS-CoV-2 was declared a pandemic on March 11,
2020. It utilizes angiotensin-converting enzyme 2 (ACE2) receptor in
renin-angiotensin system (RAS) for viral entry. ACE2 is identified in
female and male reproductive systems and reports of multi-organ
involvement has led to uncertainty regarding its effects on reproductive
systems and fertility. We review existing literature regarding function
of ACE2 and RAS in reproductive systems to postulate the implications
SARS-CoV-2 may have on fertility and assisted reproductive technology
(ART) outcomes. ART guidelines from different fertility societies are
provided for management of ART patients and for ART laboratory
regulations.