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Biosensors functionalized with nanoparticles for rapid detection of Brucella
  • Azam Ahangari,
  • Pezhman Mahmoodi,
  • Abdolmajid Mohammadzadeh
Azam Ahangari
Bu Ali Sina University
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Pezhman Mahmoodi
Bu Ali Sina University
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Abdolmajid Mohammadzadeh
Bu Ali Sina University
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Abstract

Brucellosis is an infectious bacterial disease that mainly affects ruminants and humans and its detection is still a significant challenge in particular, in the developing countries. At present, methods used to diagnose brucellosis consist of microbiological, biochemical, immunological, and molecular techniques which may be time-consuming, laborious, expensive, and dependent on special equipment, while they may not be suitable for on-site miniaturized detection. Thus, development of novel methods that can characterize Brucella spp with minimal equipment is invaluable for rapid and easy detection of these pathogenic bacteria especially in basic laboratories or even in the farm fields. The nanotechnology-driven approach can be successfully applied using different nanoparticles for the diagnosis of pathogens. Nanobiosensors are therefore, one of those promising solutions in this case. These sensors are efficient tools with diverse biological applications which can identify pathogenic bacteria with relatively high sensitivity and specificity. In this context, new nanobiosensors, developed based on various nanoparticles, for rapid detection of Brucella spp have been discussed.

Peer review status:UNDER REVIEW

13 Apr 2021Submitted to Biotechnology and Bioengineering
13 Apr 2021Assigned to Editor
13 Apr 2021Submission Checks Completed
04 May 2021Reviewer(s) Assigned