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APATHY & COGNITIVE SYMTOMS IN DEEP BRAIN STIMULATION
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  • Selim Polat,
  • Miray Erdem,
  • Gökhan Çavuş,
  • Melih Çekinmez
Selim Polat
SBÜ Adana Şehir Eğitim ve Araştırma Hastanesi

Corresponding Author:selim.md.polat@gmail.com

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Miray Erdem
SBÜ Adana Şehir Eğitim ve Araştırma Hastanesi
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Gökhan Çavuş
SBÜ Adana Şehir Eğitim ve Araştırma Hastanesi
Melih Çekinmez
SBÜ Adana Şehir Eğitim ve Araştırma Hastanesi
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Abstract

Objective: The aim of this research was to elucidate the effect of deep brain stimulation on apathy, and cognitive functions in the pre and post-operative period. Materials & Methods: This study was conducted in Adana City Training & Research Hospital, Parkinson and Movement Disorders Center between January to December 2022. Individuals were evaluated by a multidisciplinary commission consisting of neurology, neurosurgery and psychiatrists. Eighteen patients, aged between 18–70 years who underwent Deep Brain Stimulation at the neurosurgery clinic were included in the study. Hamiltonanxiety and depression, apathy assessment, standard mini-mental test and Montreal Cognitive Assessment scales are applied to the patients. Results: The mean Apathy Score at the pre-op was 47.77±15.83 in patients who had undergone DBS operation while it was 30.83±13.59 in the post–op. This decrease was statistically significant (p<0.003) and indicated clinical improvement. The average Hamilton Anxiety scale scores at the pre–op was 11.50±5.14, and s 10.22±5.57 at the post-op with no clinical significance (p=0.28). The UPDRS-ON value was determined as 22.55±7.53 in the pre–op and 14.50±6.99 in the post–op significantly (p<0.001). UPDRS-OFF was found to be significant with pre–op 37.44±9.85, compared to post–op 23.44±7.86 (p<0.001). Conclusion: Regarding the results of this study, it was found that sub – thalamic stimulation led to stabilization of both motor and non-motor complications. Additionally DBS ameliorated apathy and Parkinson’s Disease symptoms of patients significantly. Future studies with larger sample size that focus on both pharmacological and non-pharmacological treatments might provide better clinical aspects.