Any association between pediatric B-Cell Lymphoblastic Leukemia
following SARS-CoV-2 infection: a case series
Abstract
COVID-19 infection is still a mystery in terms of its long-term effect
on health and its consequences on hematological disorders. In this
article, we are presenting two cases of pediatric B-lymphoblastic
leukemia (B-ALL) with a previous history of COVID-19 infection. Notably,
in both the cases the fluorescence-in situ hybridization (FISH) studies
showed pathologic alteration of the RUNX1 gene. The finding of this
genetic alteration along with known pre-leukemic translocation
ETV6-RUNX1, opens a door for further exploration of the “second-hit”
hypothesis regarding an infectious agent precipitating development of
B-ALL in a genetically susceptible individual.