Sickle cell disease (SCD) is a common inherited blood disorder of public health concern in India. Individuals with SCD may encounter stigma, discrimination, and misconceptions about their condition, leading to feelings of isolation and frustration. It is important to note that the psychological impact of SCD can vary among individuals. Some may develop resilience and coping strategies to manage the challenges, while others may require additional support from healthcare professionals, psychologists, or support groups to address their psychological needs. The multidisciplinary approach involving medical care, psychological support, and social interventions is crucial in improving the overall well-being of individuals living with sickle cell disease. While the clinical aspects of SCD are significant, it’s also important to consider the psychological aspects that can affect individuals with the condition. In this context, there is a pressing need for societal support pillars which empower SCD patients and improves their quality of life. In this context, there is a pressing need for societal support pillars which empower SCD patients and improves their quality of life. The impact of societal support pillars on SCD patients is substantial. Strengthening healthcare systems, fostering robust social support networks, facilitating inclusive educational environments, and raising public awareness are integral components of comprehensive care for individuals living with SCD. All these pillars can significantly improve the quality of life and outcomes for SCD patients, ultimately leading to a more inclusive and supportive society.