Hematological Features and Risk Factors of Hospitalized COVID-19
Patients: A Retrospective Analysis
Abstract
Background: Coronavirus disease 2019 (COVID-19) has become pandemic in
2020 and recently mutated coronavirus has emerged in many countries.
This study firstly identified the clinical characteristics and risk
factors for COVID-19 patients in Zhengzhou for clinical prevention and
management. Methods: A total of 70 patients hospitalized with COVID-19
were enrolled between 21th January and 29th February 2020, in Zhengzhou,
China. Clinical characteristics, hematological findings, neutrophil
lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and inflammatory
index on admission were selected from medical records and the comparison
between COVID-19 patients with different outcomes were evaluated.
Results : The median age was 55 years. Forty-three (43%) patients were
classified as severe or critical cases. Eighteen (12.8%) patients died
in hospital and the remaining fifty-two were discharged. Patients who
died tend to old aged, expectoration, with chronic obstructive pulmonary
disease. Compared to survivor, non-survivor has significantly higher
leucocytes, neutrophils, NLR, AST, GGT, TBIL, DBIL, LDH, PT, D-dimer,
CRP, and decreased platelet, lymphocyte, UA, ALB, CHE, PTA. Multiple
logistic regression analysis identified leucocytes, platelet, PLR, NLR,
AST, and ALB as independent factors for poor outcomes. The AUC of
combination of leucocyte, PLR, NLR, and AST have the largest area under
curve at 0.87, with the sensitivity of 0.83 and specificity of 0.81.
Conclusion : Our results identified the risk factors among COVID-19
patients in-hospital fatality. Leucocyte, PLR, NLR, and AST could have
important reference value for prognostic prediction and early
intervention.