Abstract

not-yet-known not-yet-known not-yet-known unknown Background: Hepatoid adenocarcinoma (HAC) is an extrahepatic adenocarcinoma characterized by hepatoid differentiation, often associated with elevated serum alpha-fetoprotein (AFP) levels. The stomach is the most common site of HAC, and this is specifically identified by the term hepatoid adenocarcinoma of the stomach (HAS). Case: We present a case of a 71-year-old patient who was immunohistologically diagnosed with HAS along with both liver metastasis and pancreatic metastasis. Sindilizumab+ albumin paclitaxel+ 5-fluorouracil+ calcium folinate/ cyclophosphamide was started after the disagreement of surgical treatment. After 6 months treatment, both primary and metastatic lesions visibly shrank and imaging examinations did not reveal the presence of local recurrence or other distant metastasis. Conclusion: More research is still needed for HAS, especially for special cases with multiple metastases simultaneously.