Method
173 consecutive mCRPC patients treated with 223Ra were
included in this prospective study. QoL was assessed through EORTC
QLQ-C30 and QLQ-BM22 Questionnaires and 2264 questionnaires were
evaluated. Other baseline variables relevant to the OS analysis have
been considered. Data were summarized using descriptive statistics,
univariate and multivariate analysis with Cox model. A principal
component analysis (PCA) on the questionnaires’ results compiled at
baseline was performed to reduce the data to a one-dimensional score.
Joint models for survival and longitudinal data were finally used in
order to evaluate the relationship between the time-depended QoL scores
and OS.