Effect of different TVs on muscle pressure
In our simulated lungs, measured driving pressure at the carina was represent inspiratory muscle activity. We observed that muscle activity in the obstructive lung model was greater than that in the normal and restrictive lung disease models, regardless of f and VTsettings in our experiment. However, the trend of decreased driving pressure was more profound in the largest VT (700mL) than in the small (300mL) and normal (500mL) VT. For example, with an RR of 30breaths/min, driving pressure decreased from −2.1 to −7.4cmH2O, −2.4 to −9.3cmH2O and −3.5 to −15.4cmH2O in the normal, restrictive and obstructive lung mechanics settings, respectively, for VT of 300, 500 and 700mL (Fig. 4).