Figure 2. The expression and localization of intra-islet heparanase (HPSE) in control and streptozotocin (STZ)-induced diabetic mice. (A) Representative images of HPSE immunohistochemical staining of the islets in control and STZ mice. Scale bar=50 μm. (B) Integral optical density (IOD) of HPSE immunohistochemical staining based on islet area in control and STZ mice, **p<0.01, n=10. (C) The expression of HPSE in different islet cell types from single cell sequencing data. (D) Representative images of HPSE and monocytes (F4/80) staining, (E) HPSE and insulin staining in islets from control and STZ mice. Immunofluorescence followed by DAPI staining. Scale bar, 50 μm.