Figure 5. OGT2115 increased intra-islet HS levels and reduced the infiltration of monocytes in STZ mice. (A) Representative images of Alcian Blue histochemical staining and heparan sulfate (HS), F4/80, CD8, and CD4 immunohistochemical staining of the islets in each OGT2115 treatment group. Scale bar=50 μm. (B) Optical density of HS immunohistochemical staining based on islet area in the different treatment groups. (C) Percentage of F4/80 and (D) CD8/CD4-positive cells in the islets of the different treatment groups. **p<0.01, ***p<0.001, ns=not significant as indicated, at least 10 islets were detected in each section from different group, n=10.