Figure 3. Recommendations to describe the measured pathway
process and molecules.
A) Terms to describe the measured pathway process. Also see
reviews describing the translation across these levels (Luttrell,
Maudsley & Gesty-Palmer, 2018), assays (Smith, Lefkowitz & Rajagopal,
2018) and animal models (Bradley & Tobin, 2016).
B) Data from (Klein Herenbrink et al., 2016) shows the relative
bias of dopamine D2 receptor agonists for six pathways
(all with dopamine as the reference ligand). The relative order of the
biased ligands changes depending on the measured molecules, even across
those participating in the same pathway. This emphasizes that bias
should be measured at similar pathway depths (as proximal/distal to the
receptor), each of which should be defined with respect to the measured
molecules.