Author contributions
Shuai Tu was responsible for drafting the manuscript, performing experiments, data analysis, and revision. Feng Xiao was responsible for the acquisition of metabolomics data, study conception, and design. Chengyu Mei and Shuang Li reviewed and revised the manuscript. Pei Qiao guided data processing and manuscript revision. Ziyan Huang and Zhixing Gong performed experiments. Weihong Zhong was responsible for funding acquisition, project administration, supervision, and revision.