Authors
Origin (years)
Study type
Population
Mean duration of follow-up
Association between IT and recurrence
Christiansen et al [33]
Netherlands (2005)
Prospective cohort
474 patients with a firts VTE
7.3 years
HR=1.4 ; IC= 0.9-2.2 HR=1.6 IC=1-2.7
Santamaria et al [21]
Italy (2005)
Randomized mulicentric prospective study
195 patients with first proximal unprovoked VTE
46,8 months
HR=1.78, p=0.046
Douketis et al [24]
Canada (2010)
Meta-analysis of 7 prospective studies
1818 patients with first unprovoked VTE
26.9 months
HR=1 ; p=1
Kudo et al [34]
Australia (2016)
Retrospective multicentric study
152 patients with an index VTE
1 year
Patients with recurrent VTE had a higher rate of positive thrombophilia results (52% vs 27% (p=0.007)
Lim et al [13]
Australia (2017)
Retrospective study
742 patients with an index VTE
27 months
HR= 1.19 ;p= 0.74
Satpanich and Rojnuckarin [22]
Thai (2018)
Retrospective cohort
198 patients with an index VTE
52 months
HR= 3.52 ; p = 0.01