Fig. 8. Overview of affected pathways of identified 59 significantly
altered metabolites after the treatment with second generation mTOR
inhibitor (PP242) at an oral dose of 60
mg.kg-1.day-1 for three weeks. The
major perturbed metabolic pathways associated with PP242 effects were
energy metabolism, fatty acid metabolism and glycerophospholipid
metabolism. Grey color represents increased metabolites after the mTOR
inhibition by PP242; dark grey color represents decreased metabolites
after the mTOR inhibition by PP242 [grey and dark grey box indicates
the identified metabolites that are significantly altered].