Introduction:
Lymphoma is a cancer of the lymphatic system which is classified as Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL).
Oral lymphomas are the third most common malignancies after squamous cell carcinoma in the oral cavity which accounts for 3% of all lymphomas.[1]
Primary Extranodal lymphoma represents 25-40 % of all non-Hodgkin lymphoma (NHL) [2]
In addition, 2% to 3% of these extranodal cases derive primarily in the oral cavity [3]
And most commonly affects the Waldeyer’s ring and only 2% of these tumors are located on the buccal floor. [4]
The most common lineage of lymphomas are B cells (98%), and the majority of these B cells are histologically subtyped as diffuse large B cell lymphoma.[3]
Oral Peripheral T-cell lymphomas (PTCLs) are uncommon subtypes of non-Hodgkin lymphoma (NHL) that only a few cases have been reported in the literature but it should always be considered in the differential diagnosis of oral cavities.
Herein, we describe an extremely rare case of peripheral T-cell lymphoma which derives primarily from buccal mucosa in a 34-year-old patient.
The patient was diagnosed as a PTCLs based on a biopsy and immunohistochemistry and was referred to the oncology department for chemoradiotherapy.