Inhibitors
All patients in the PedNet Registry are followed regarding development
of inhibitors in regular annual follow-ups. Inhibitors are divided into
low- and high-titer inhibitors according to international guidelines
(Blanchette, et al 2014). In this study, inhibitors are reported
for the new variants in order to support clinical information on this
specific variant. Following international standards, low-titer
inhibitors were defined as ≤ 5 BU (Bethesda Units) and high responder as
> 5 BU.