Phenotype of hemophilia
The PedNet Registry follows the international classification for hemophilia valid when the Registry was initiated (i.e .: severe form FVIII/FIX <1%, moderate 1–5% and mild with 6–25%) and not the present classification where mild form is defined as 6–40% (Blanchette, et al 2014). FVIII/FIX levels were measured at each participating center according to local standards. Both chromogenic and one-stage assay methods were accepted.