Inhibitors
All patients in the PedNet Registry are followed regarding development of inhibitors in regular annual follow-ups. Inhibitors are divided into low- and high-titer inhibitors according to international guidelines (Blanchette, et al 2014). In this study, inhibitors are reported for the new variants in order to support clinical information on this specific variant. Following international standards, low-titer inhibitors were defined as ≤ 5 BU (Bethesda Units) and high responder as > 5 BU.