Phenotype of hemophilia
The PedNet Registry follows the international classification for
hemophilia valid when the Registry was initiated (i.e .: severe
form FVIII/FIX <1%, moderate 1–5% and mild with 6–25%)
and not the present classification where mild form is defined as 6–40%
(Blanchette, et al 2014). FVIII/FIX levels were measured at each
participating center according to local standards. Both chromogenic and
one-stage assay methods were accepted.