Figure Legends
Figure 1 : A) Linear regression of average case fatality
rate (CFR Average; Y-axis) with percentage of viruses exhibiting an
aspartate (D) at amino acid position 614 in the viral envelope spike
protein (Percentage D614; X-axis). B) Same linear regression as A
but using median CFR. C) Table of underlying data used in the
regression.
Figure 2 : A) Location of D614 (CPK depiction; arrow) in viral
envelope trimeric spike structure. B) close-up of D614 showing optimal
packing with T858 in adjacent monomer helical stalk, which would result
in a cavity upon mutation to G614, which has no side chain. C) Energy
calculation for D to G mutation for different 3D structural
conformations of the SARS-CoV-2 viral spike.
Figure S1: Linear regression of average and median CFR analysis
with United Kingdom included (red dot).