Conclusion
This case highlights the importance of keeping a high suspicion and diagnosing the pathology at the earliest to treat and control the disease in these critically ill patients. Though they may be immunocompetent and with no risk factors prior to admission to the ICU, they become vulnerable and the risk of developing primary/latent CMV infection is high. A timely diagnosis can prevent prolonged ICU and hospital stay. It also warrants judicious use of corticosteroids and other immunomodulatory drugs like tocilizumab in critically ill patients. In the present Scenario, while treating patients with COVID-19 with the use of immunosuppressive therapy should be justified while being alert for signs and symptoms of CMV reactivation. Early recognition of CMV infection and initiation of early treatment will prevent life-threatening bleeding and mortality.