Code Detailed classification N (%)
Problems Problems
P1 Treatment effectiveness 282(53.71%)
P1.1 No effect of drug treatment 51(9.71%)
P1.2 Effect of drug treatment not optimal 158(30.10%)
P1.3 Untreated symptoms or indication 73(13.90%)
P2 Treatment safety 178(33.90%)
P2.1 Adverse drug event (possibly) occurring 178(33.90%)
P3 Other 65(12.38%)
P3.1 Problem with cost-effectiveness of the treatment 14(2.67%)
P3.2 Unnecessary drug-treatment 51(9.71%)
Causes Causes
C1 Drug selection 375(71.43%)
C1.1 Inappropriate drug according to guidelines/formulary 34(6.48%)
C1.2 Inappropriate drug (within guidelines but otherwise contra-indicated) 106(20.19%)
C1.3 No indication for drug 26(4.95%)
C1.4 Inappropriate combination of drugs, or drugs and herbal medications, or drugs and dietary supplements 30(5.71%)
C1.5 Inappropriate duplication of therapeutic group or active ingredient 34(6.48%)
C1.6 No or incomplete drug treatment in spite of existing indication 145(27.62%)
C2 Drug form 23(4.38%)
C2.1 Inappropriate drug form (for this patient) 23(4.38%)
C3 Dose selection 108(20.57%)
C3.1 Drug dose too low 38(7.24%)
C3.2 Drug dose too high 29(5.52%)
C3.3 Dosage regimen not frequent enough 17(3.24%)
C3.4 Dosage regimen too frequent 13(2.48%)
C3.5 Dose timing instructions wrong, unclear or missing 11(2.10%)
C4 Treatment duration 19(3.62%)
C4.2 Duration of treatment too long 19(3.62%)
Planned interventions Planned interventions
I1 At prescriber level 525
I1.2 Prescriber asked for information 6(1.14%)
I1.3 Intervention proposed to prescriber 505(96.19%)
I1.4 Intervention discussed with prescriber 14(2.67)
I3 At drug level 525
I3.1 Drug changed to 256(48.76%)
I3.2 Dosage changed to 130(24.76%)
I3.3 Formulation changed to 8(1.52%)
I3.4 Instructions for use changed to 12(2.29%)
I3.5 Drug paused or stopped 58(11.05%)
I3.6 Drug started 61(11.62%)
Intervention Acceptance Intervention Acceptance
A1 Intervention accepted 485(92.38%)
A1.1 Intervention accepted and fully implemented 475(90.48%)
A1.3 Intervention accepted but not implemented 10(1.90%)
A2 Intervention not accepted 40(7.62%)
A2.2 Intervention not accepted: no agreement 26(4.95%)
A2.3 Intervention not accepted: other reason (specify) 14(2.67%)