INTRODUCTION
Polycystic ovary syndrome (PCOS) is a prevalent endocrinopathy that
affects 8–13% of reproductive age women (1). it is characterized by
hyperandrogenism, ovulatory dysfunction, and polycystic ovaries (2).
These women have a higher incidence of developing complications such as
type II diabetes, obesity, hypertension, dyslipidemia, and
cardiovascular system diseases(3). Moreover, PCOS has a psychological
impact with increased depression and anxiety that can result in
worsening of quality of life for these patients (4). The exact mechanism
underlying PCOS is unclear (5). The genetic contribution to PCOS remains
uncertain, and no particular environmental factor has been identified as
causing PCOS (6). Women with PCOS is characterized by high plasma level
of ovarian and adrenal androgens, abnormal gonadotropin secretion,
reduced serum levels of sex hormone-binding globulin (SHBG), and often
high serum level insulin (7), as a result of insulin resistance (8).
Obesity is a comorbidity that may intensify the effects of PCOS (9).