Side effect
The most common side effects of oral isotretinoin are dry mucous membranes, dry skin, dry lip, dry eyes, and nose bleed (47). The most important side effects are increased levels of total cholesterol, serum triglycerides and liver enzymes (48). In women of childbearing age, oral contraceptives should be used during and for one month after therapy to avoid pregnancy because of the teratogenicity effect of oral Isotretinoin (49).