Retinoids
Retinoidscontrol the formation of microcomedones, decrease the formation of lesions and existing comedones, decrease sebum production and normalize keratinization. Moreover, they may also demonstrate anti-inflammatory properties (65, 66).  Different topical preparations are available such as creams, gels, foams, solutions, and lotions in a wide range of concentrations (67). Topical retinoids are associated with skin dryness, erythema, and pain, and may exacerbate dermatitis or eczema (67). Daily sunscreen use is recommended due to increased sun-sensitivity and is best used in the evening (68). Limited use of topical retinoids during pregnancy because of the known teratogenic effect of similar oral retinoids (69).