DIAGNOSIS OF POLYCYSTIC OVARY SYNDROME
According to the Rotterdam 2003 criteria, diagnosis requires the
presence of at least two of the following three findings:
hyperandrogenism, ovulatory dysfunction, and polycystic ovaries (10).
The National Institutes of Health (NIH) in 1990 recommended
hyperandrogenemia and oligo-anovulation as the two criteria that are
required to diagnose PCOS (11). While in 2009, Androgen Excess and PCOS
Society (AE-PCOS) concluded that PCOS should be based only on clinical
or biochemical hyperandrogenism, and ovarian dysfunction (12). In 2012,
NIH Consensus (NIH and ESHRE/ASRM) recommended broader wider
Rotterdam/ESHRE/ASRM 2003 criteria with detailed PCOS phenotype of all
PCOS, owing to controversies among diagnostic criteria (13). Two of the
three criteria (hyperandrogenism, ovulatory dysfunction, and polycystic
ovarian morphology) are required for diagnosis. In addition, each case
has to classify categorize into a specific definite phenotype as
Phenotype A: hyperandrogenism + ovulatory dysfunction + polycystic
ovarian morphology; Phenotype B: hyperandrogenism + ovulatory
dysfunction; Phenotype C: hyperandrogenism + polycystic ovarian
morphology; and Phenotype D: ovulatory dysfunction + polycystic ovarian
morphology (14, 15).