ACEi/ARB: angiotensin-converting-enzyme inhibitor/angiotensin receptor blocker; CCI: Charlson comorbidity index; eGFR: estimated glomerular filtration rate; LVEF: left ventricular ejection fraction.

FIGURE LEGENDS

Figure 1: Study flowchart

Figure 2: Dissimilarity matrix defined by Kendall distance and multiscale bootstrap resampling. In the matrix square, the color level is proportional to the similarity value between the observations. If it is red, the distance between the variables is 0 (high similarity) and if it is green, the distance is the highest (low similarity). In the multiscale bootstrap resampling [approximately unbiased probability (AU) in red; bootstrap probability (BP) in green]. The greater the value of both, the more significantly representative the grouping of the variables included.

Panel A: Patients with HFpEF and T2DM. Panel B: Patients with HFpEF and without T2DM.

BMI: body mass index; COPD: Chronic obstructive pulmonary disease; eGFR: estimated glomerular filtration ratio by MDRD formula; HB: hemoglobin; SBP: systolic blood pressure.

Figure 3: Descriptive figure of the clusters (above) and Kaplan Meier curves (below).

Supplementary figure 1: Dendrograms of patients with and without type 2 diabetes mellitus, with their corresponding clusters.

APPENDIX 1

Membership of RICA registry:

Álvarez Rocha P, Anarte L, Arévalo-Lorido JC, Carrascosa S, Carretero-Gómez J, Cepeda JM, Díez-Manglano J, Epelde F, Fabra Juana S, García Escrivá D, García López P, Gómez Huelgas R, González Franco A, León Acuña A, Llàcer P, López-Castellanos G, Manzano L, Montero-Pérez-Barquero M, Ormaechea G, Pérez Silvestre J, Quesada Simón MA, Roca Villanueva B, Ruiz Ortega R, Soler Rangel ML, Suárez Pedreira I, Trullàs JC.