1. |
Type I Diabetes |
Resistance of Teff cells to Treg mediated
suppression via faster activation of STAT3 signaling post TCR
stimulation in Type-1 diabetes patients |
[62] |
|
|
Effector T cells from type 1 diabetes patients are resistant to
suppression mediated by CD4+CD25+
Treg cells. |
[63, 64] |
2. |
Rheumatoid Arthritis |
Synovial CD161+Th17 cells
are resistant to Treg mediated suppression in rheumatoid arthritis
patients |
[65] |
3.
|
HIV Infection
|
Increased sensitivity of CD4+CD25-
Teff cells to Treg mediated suppression in HIV+
asymptomatic individuals compared to progressors.
HLA-B*27 and HLA-B*57 restricted CD8+ T cells
associated with protection against HIV are not suppressed by Treg
cells.
|
[66, 67]
|
4. |
Tuberculosis |
HLA-DR+CD4+
memory T cells which are
IFN-γhiIL-2hiIL-17hiIL-22hi
are resistant to Treg mediated suppression in TB patients. |
[61] |