Sl. No Clinical Condition Finding Reference
1. Type I Diabetes Resistance of Teff cells to Treg mediated suppression via faster activation of STAT3 signaling post TCR stimulation in Type-1 diabetes patients [62]
Effector T cells from type 1 diabetes patients are resistant to suppression mediated by CD4+CD25+ Treg cells. [63, 64]
2. Rheumatoid Arthritis Synovial CD161+Th17 cells are resistant to Treg mediated suppression in rheumatoid arthritis patients [65]
3.
HIV Infection
Increased sensitivity of CD4+CD25- Teff cells to Treg mediated suppression in HIV+ asymptomatic individuals compared to progressors. HLA-B*27 and HLA-B*57 restricted CD8+ T cells associated with protection against HIV are not suppressed by Treg cells.
[66, 67]
4. Tuberculosis HLA-DR+CD4+ memory T cells which are IFN-γhiIL-2hiIL-17hiIL-22hi are resistant to Treg mediated suppression in TB patients. [61]