Figure 1. Post-translational modifications of CD36.
There are two ubiquitination sites on the N-terminus of CD36, Lys472, Lys469. CD36 ubiquitination level decreases upon insulin stimulation while increases with the presence of LCFA; Parkin is CD36’s E3 ubiquitin ligase, which monoubiquitinates CD36 and enhances its stability, while USP14 mediates CD36 deubiquitination; There are four palmitoylation sites at the C-terminus and the N-terminus of CD36, Cys3, Cys7,Cys464, Cys466, DHHC4/5 are palmitoyltransferases that promote palmitoylation of CD36; CD36 also has two phosphorylation sites, Thr93 and Ser237, which are phosphorylated by PKC and PKA, respectively. LCFA, long chain fatty acid; USP14, ubiquitin specific peptidase 14; DHHC, Asp-His-His-Cys; PKA, protein kinase A; PKC, protein kinase C; IAP, Intestinal alkaline phosphatase