Figure 1. Post-translational modifications of CD36.
There are two ubiquitination sites on the N-terminus of CD36, Lys472,
Lys469. CD36 ubiquitination level decreases upon insulin stimulation
while increases with the presence of LCFA; Parkin is CD36’s E3 ubiquitin
ligase, which monoubiquitinates CD36 and enhances its stability, while
USP14 mediates CD36 deubiquitination; There are four palmitoylation
sites at the C-terminus and the N-terminus of CD36, Cys3, Cys7,Cys464,
Cys466, DHHC4/5 are palmitoyltransferases that promote palmitoylation of
CD36; CD36 also has two phosphorylation sites, Thr93 and Ser237, which
are phosphorylated by PKC and PKA, respectively. LCFA, long chain fatty
acid; USP14, ubiquitin specific peptidase 14; DHHC, Asp-His-His-Cys;
PKA, protein kinase A; PKC, protein kinase C; IAP, Intestinal alkaline
phosphatase