Figure legends:
Figure 1. Model validation. (a) Prediction of
Carmichael et al. PK data (200 mg daily). Blue line: median. Black
lines: 2.5 and 97.5 percentiles (95 % prediction interval). Red starts:
observed (blood) concentrations in RA patients digitised from Carmichael
et al. publication [3]. (b-e) Prediction of Morita et al.
PK data for different dosing regimens: (b) 200 mg daily (c) 200 or 400
mg every other day, when the last dosing just before blood sampling is
200 mg (d) 200 or 400 mg every other day, when the last dosing just
before blood sampling is 400 mg (e) 400 mg daily. Blue line: medians.
Black lines: 2.5 and 97.5 percentiles (95 % prediction intervals). Red
starts: observed (blood) concentrations in CLE patients digitised from
Morita et al. publication [4] (f) Prediction of Gautret et
al. PK data (200 mg TID for 10 days). Blue line: median. Black lines:
2.5 and 97.5 percentiles (95 % prediction interval). Stars: observed
corrected serum concentrations in COVID-19 patients from Gautret et al.
publication [6] (blue/black refers to PCR-negative patients on day
6, red refers to PCR-positive patients on day 6, black refers to
patients with azithromycin added to HCQ treatment).
Figure 2. Simulated blood PK profiles for different dosing
regimens: (a) 400 mg BID on day 1 followed by 200 mg BID
(Belgian protocol ), (b) 600 mg BID on day 1 followed
by 200 mg BID, (c) 200 mg TID on day 1 followed by 200 mg BID,(d) no loading dose, 200 mg BID, (e) 400 mg BID on day
1 followed by 400 mg daily, (f) 800 mg and 400 mg 6 hours later
on day 1, followed by 200 mg BID.
Blue lines: medians. Black lines: 5th and
95th percentiles (90 % prediction intervals). Solid
lines: treatment for 10 days. Dotted lines: treatment for 5 days.
Figure 3. Histogram of times to discharge for patients of Saint
Pierre hospital.