Dosing regimen Loading dose (D1) Total loading dose Maintenance dose Total daily dose Duration of treatment
scenario 0(a) 400 mg BID 800 mg 200 mg BID 400 mg 5 days
400 mg BID 800 mg 200 mg BID 400 mg 10 days
Alternative scenario 0 / / 200 mg TID 600 mg 10 days
Alternative scenario 1 (b) 600 mg BID 1200 mg 200 mg BID 400 mg 5 days
600 mg BID 1200 mg 200 mg BID 400 mg 10 days
Alternative scenario 2 (c) 200 mg TID 600 mg 200 mg BID 400 mg 5 days
200 mg TID 600 mg 200 mg BID 400 mg 10 days
Alternative scenario 3 (d) / / 200 mg BID 400 mg 5 days
/ / 200 mg BID 400 mg 10 days
Alternative scenario 4 (e) 400 mg BID 800 mg 400 mg daily 400 mg 5 days
400 mg BID 800 mg 400 mg daily 400 mg 10 days
Alternative scenario 5 (f) 800 mg followed by 400 mg 6 hours later 1200 mg 200 mg BID 400 mg 5 days
800 mg followed by 400 mg 6 hours later 1200 mg 200 mg BID 400 mg 10 days