5. Limitations
Our study is not without limitations. First, we were not able to address sensitivity and specificity of drug challenge testing by meta-analysis because of insufficient data provided in included articles. Secondly, four different SCB were used across the studies- likely the main source of cause heterogeneity in our results (SCB and doses are shown in Table 1). Moreover, for the pooled OR of ventricular tachyarrhythmia during drug challenge testing, extracted data from the included studies were not all adjusted for other variables and may be influenced by other confounders.