2.1 Search strategy
Two investigators (WV and PP) independently searched for published studies indexed in MEDLINE and EMBASE databases from inception to August 2019 using a search strategy that including the terms “sodium channel blocker”, “ajmaline”, “pilsicainide”, “flecainide”, “procainamide”, and “Brugada syndrome” as described in supplementary file 1. Only full articles in English and studies conducted in cohorts were included. A manual search for additional pertinent studies and review articles using references from retrieved articles was also completed.