2.1 Search strategy
Two investigators (WV and PP) independently searched for published
studies indexed in MEDLINE and EMBASE databases from inception to August
2019 using a search strategy that including the terms “sodium channel
blocker”, “ajmaline”, “pilsicainide”, “flecainide”,
“procainamide”, and “Brugada syndrome” as described in supplementary
file 1. Only full articles in English and studies conducted in cohorts
were included. A manual search for additional pertinent studies and
review articles using references from retrieved articles was also
completed.