Funding
This study was supported by National Natural Science Foundation of China (81670656,81870508, funder SXL), China Postdoctoral Science Foundation (2017M612624, funder RYL),Natural Science Foundation of Guangdong Province (2014A030313544, funder CSH), Guangdong Science and Technology Fund (2014A020209001, funder CSH),Guangdong Medical Science and Technology Research Fund (A2017564, funder RYL), Guangzhou City Science and Technology Project (201707010009, funder SXL). These funding support part treatment fee.