METHODS
We performed a systematic literature research in three stages (see Figure 1 ): First, we searched PubMed, EMBASE and CINAHL using the following terms: “(((SARS-CoV-2) OR (COVID-19)) AND ((systematic review)) AND ((children 0-18 years of age)))” to find systemic reviews on the topic, and then reviewed the primary studies included in those reviews. Second, we searched PubMed for “(((COVID-19) OR (SARS-CoV-2)) AND ((asthma) OR (wheezing)))”, to directly find any studies on asthma/wheezing and COVID-19 (without an age filter), and evaluated whether they included pediatric populations. Third, we repeated search #2 in BioRxiv.org and MedRxiv.org to evaluate whether existing pre-prints may have relevant pediatric asthma information. The last update of the searches was on May 6, 2020. (see Figure 1 ).
Both authors (JCR, EF) independently screened and retrieved articles. The same investigators independently assessed full texts of those primary studies included in the systematic review identified. Any discrepancies were resolved by discussion and consensus. If sufficient studies with relevant data were found, the plan was to perform a meta-analysis by asthma status. The review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines(7).