METHODS
We performed a systematic literature research in three stages (see Figure 1 ): First, we searched PubMed, EMBASE and CINAHL using
the following terms: “(((SARS-CoV-2) OR (COVID-19)) AND ((systematic
review)) AND ((children 0-18 years of age)))” to find systemic reviews
on the topic, and then reviewed the primary studies included in those
reviews. Second, we searched PubMed for “(((COVID-19) OR (SARS-CoV-2))
AND ((asthma) OR (wheezing)))”, to directly find any studies on
asthma/wheezing and COVID-19 (without an age filter), and evaluated
whether they included pediatric populations. Third, we repeated search
#2 in BioRxiv.org and MedRxiv.org to evaluate whether existing
pre-prints may have relevant pediatric asthma information. The last
update of the searches was on May 6, 2020. (see Figure 1 ).
Both authors (JCR, EF) independently screened and retrieved articles.
The same investigators independently assessed full texts of those
primary studies included in the systematic review identified. Any
discrepancies were resolved by discussion and consensus. If sufficient
studies with relevant data were found, the plan was to perform a
meta-analysis by asthma status. The review was performed following the
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
(PRISMA) guidelines(7).