Introduction
Primary spinal epidural lymphomas (PSELs) comprise a group of tumors,
which are present only in the spinal epidural space, with a
histopathological picture of lymphoma, and negative diagnostic workup
for lymphoma at other sites.1 Epidural location of
lymphomas, both Hodgkin’s and non-Hodgkin’s is very rare due to which
the diagnosis is challenging. About 24-48% of non-Hodgkin’s lymphomas
(NHLs) were found to have extranodal origin.2,3However, PSEL accounts for only 0.9% of all extranodal
NHLs.4 There are many cell types of NHLs, DLBCL is the
most common form which accounts for only 1.8% of all (nodal and
extranodal) DLBCLs.5 It is easily missed and maybe
misdiagnosed leading to lack of timely intervention and unhindered
progression of the tumor.
This report describes the clinical features, imaging characteristics,
and histopathological features of the rare case of primary spinal
epidural diffuse large B-cell lymphoma (DLBCL). To the best of our
knowledge, this is the first reported case of primary spinal epidural
DLBCL from Nepal. It also emphasizes the importance of a
multidisciplinary approach for the successful treatment of this disease.