Conclusion

Primary spinal epidural DLBCL is one of the rarest tumors due to which its diagnosis is challenging. Signs and symptoms are similar to those of any other epidural space-occupying lesions and thus, can be frequently misdiagnosed. Back pain with sudden neurological deterioration in lower limbs should raise the suspicion of rarer diseases like primary spinal epidural DLBCL. A high degree of suspicion along with team approach (surgeons, radiotherapist, oncologist, and pathologist) is vital for its diagnosis and management.