Mouse experiment
Female C57BL/6 wild type (WT) mice and il17a-/-mice were treated with curdlan intranasally.24-26 In
some experiment, WT mice were given anti-CXCL13 antibody or LTβR-Ig
fusion protein intraperitoneally. Histology and RT-PCR study were
performed as mentioned elsewhere.27 As previously
described,28 lymphoid aggregates with a dense
lymphocyte core and > 50 cells were defined as eLTs, and
those with fewer cells and/or dispersed lymphocyte localization were
defined as lymphocyte clusters. All mice were used following protocols
approved by the Animal Care and Use Committee of Tongji Hospital. More
information is provided in this article’s Online Supplement.