Maternal and neonatal outcomes in COVID-19 infected pregnancies: a
prospective cohort study
Abstract
Objective:To compare maternal and fetal consequences of
Covid-19-infected pregnancies with non-infected pregnancies. Design:
Prospective cohort study Setting: Iran Population: Pregnant women who
were hospitalized from March 1 to April 20 2020 Methods: Participants
were divided into three groups: Women with positive Covid-19 PCR test
and/or positive CT scan findings in the presence of very typical
clinical symptoms were classified as confirmed group,women with typical
clinical symptoms along with two or more oflaboratory findings were
classified as probable group and women who hadno clinical symptom of
infection were classified as a control group.In order to minimize the
presence of asymptomatic individuals in the control group, we used very
precise exclusion criteria. Main Outcome Measures: Maternal, neonatal
and pregnancy outcomes. Results:One hundred and eighty-two women
enrolled including37 and 12 and 133 women inconfirmed, probable
andcontrol groups respectively.Caesarean Section was carried outin total
96 women (52.74%,95%CI:45.22,68.31).Nosignificant association was
found between COVID-19 infection and preterm
labour(aRR:0.75,95%CI:0.30,1.87,P=0.546),low birth
weight(aRR:1.15,95%CI:0.49,2.73,P=0.737), gestational
diabetes(aRR:0.78,95%CI:0.26,2.33,P=0.669), preeclampsia
(aRR:2.07,95%CI:0.50,8.47,P=0.310) intrauterine growth
restriction(aRR:0.30, 95%CI:0.02,3.27,P= 0.327) preterm rupture of
membrane(aRR:0.38,95%CI:0.04,3.30,P=0.383), stillbirth (aRR:
1.53,95%CI:0.15,14.71,P=0.712), postpartum haemorrhage
(aRR:0.80,95%CI:0.11,5.57,P=0.829), neonatal intensive care unit
admission (aRR:1.48,95%CI:0.38,5.78,P=0.568), neonatal
sepsis(aRR:1.23,95%CI:0.68,2.20,P= 0.481) Conclusion:Given the effect
of many potential factors, such as the severity of maternal infection,
the time interval between the onset of symptoms in mother and
childbirth, and many other factors on the effect of the virus on
pregnancy outcomes, we suggest conductingmore extensive prospective
studies in this field.