V11CL70, clearance of a 70 kg adult;
V170, volume of the central compartment of a 70 kg
adult; Q270, intercompartmental clearance between the
central compartment and the first peripheral compartment of a 70 kg
adult; V270, volume of the first peripheral
compartment of a 70 kg adult; Q370, intercompartmental
clearance between the volume of the central compartment and the volume
of the second peripheral compartment of a 70 kg adult;
V370, volume of the second peripheral compartment of a
70 kg adult; \(M_{birth,38}\), proportion of completed maturation at
birth for a 38 weeks gestational age neonate; \(T_{\frac{1}{2}}\),
time to achieve 50% of postnatal clearance maturation in weeks;
\(\alpha\), shape factor; \(\beta\), shape factor to scale a postnatal
age-dependent change of body weight; b, proportional error model term;
SE, standard error; RSE, relative standard error. Standard errors were
calculated using stochastic approximation.270 |
0.191 |
0.0636 |
33.3 |