k. ■ FIGURE LEGENDS

Figure 1:
Scatter plot showing the relationship between propofol elimination clearance after three-compartment base model fit. (A) gestational age (GA, weeks), (B) postnatal age (PNA, weeks), (C) postmenstrual age (PMA, weeks) and (D) body weight (BW, kg).
Figure 2:
Goodness of fit plots; (left) observed vs population predicted concentrations, (right) observed vs individually predicted concentrations. Black full lines represent the line of unity; red full line is a loess smooth. Grey dots represent the empirically Bayesian estimates (EBEs);
Figure 3:
Visual predictive check (VPC) plots with visualized 90% prediction intervals (red and blue areas) of the 10th, 50th and 90th percentiles for the Allegaert study8 (left), the Sepúlveda12 study (middle) and the Smits study13 (right). Full lines represent the empirical percentiles. Grey dots represent the observed data.