Association of endotypes to phenotypes in the negative/ low IL-5 levels cluster group:
Nasal polyps were present in clusters 1-4 between 0% in cluster-2 to 31% in cluster-4. Asthma, but not N-ERD, was reported in 0 to 23% in clusters 1 to 4.
Cluster group with high levels of IL-5 consisted of clusters 5-7 :
The concentration of IL-5 and also total IgE values were significantly elevated in more than in three other clusters in cluster-5 and more than in five other clusters in clusters 6 and 7, ECP was significantly elevated in > 5 other clusters in cluster-5 and 7 and significantly elevated in > than in three other clusters in cluster-6.
In cluster-5 (7 CRS cases) , the levels of type-2 related chemokines eotaxin/ CCL11, TARC/ CCL17, and PARC/ CCL18 were significantly higher than in > 5 other clusters. Also, the Th1/ Th2 chemokines MCP-3/ CCL7 and MIP-1α/ CCL3 were significantly higher than > 5 other clusters. IP-10/CXCL10 and ENA-78/CXCL5 did not differ between the clusters. MPO and IL-22 were significantly elevated (> 5 other clusters), and IFNγ (not included in the cluster analysis) was present in cluster-5 (strong Th1/Th2 pattern).