Main findings
The findings of this study demonstrate that at 11-13+6weeks’ gestation in the CH groups, compared to controls, serum PLGF was
reduced in those with pre-pregnancy CH (groups 2-4) and serum sFLT-1 was
reduced in those with normal BP (groups 2-3). In addition, serum
endothelin was increased in women with CH who are hypertensive at
presentation (groups 1 and 4) but IL-6 was reduced only in those that
remained hypertensive despite antihypertensive medications (group 4).