Strengths and limitations
The strengths of this study are examination of a large population of
women with CH recruited in the first trimester of pregnancy. Exclusion
of women with underlying renal and/or liver disease has reduced the
potential for bias in the diagnosis of PE. A limitation of this study is
the absence of longitudinal measurements of angiogenic and inflammatory
factors throughout and outside of pregnancy to correlate with possible
changes that can occur during pregnancy and the postnatal period.