Strengths and limitations
The strengths of this study are examination of a large population of women with CH recruited in the first trimester of pregnancy. Exclusion of women with underlying renal and/or liver disease has reduced the potential for bias in the diagnosis of PE. A limitation of this study is the absence of longitudinal measurements of angiogenic and inflammatory factors throughout and outside of pregnancy to correlate with possible changes that can occur during pregnancy and the postnatal period.