Table 1: A, avelumab; M, mitotane; E, etoposide; D, doxorubicin; C, cisplatin; Sz, streptozotocin; V, vincristine, NA: not available; a: Complete + partial response until progressive disease or death; b: Complete + partial response. Complete response was defined as the disappearance of all clinical evidence of the tumor on physical examination or on radiography and the complete recalcification of all osteolytic metastases for a minimum of 4 weeks. Partial response required at least a 50% decrease in the measurable tumor size and ≥ 50% recalcification of osteolytic metastases for at least 4 weeks without the appearance of new lesions;c: first-line therapy: M+E+D+C or M+Sz; second-line therapy: M+E+D+CM+Sz or M+SzM+E+D+C; d: Complete + partial response. Complete response was defined as the disappearance of all clinical evidence of the tumor for a minimum of 4 weeks. Partial response required ≥ 50% decrease in the sum of the products of the perpendicular diameters of measured lesions or a decrease ≥ 30% in the sum of liver measurements below the costal margins in the right, left, and xiphoid lines for a minimum of 4 weeks.; e: Mitotane was employed after disease progression following cisplatin and etoposide treatment in patients who had not received prior mitotane treatment; f: Complete + partial response. Complete response was defined as the disappearance of all clinical evidence of the tumor on at least two successive evaluations. Partial response required a ≥ 50% decrease in the sum of the products of the perpendicular dimensions of all measurable lesions on at least 2 evaluations; g: Complete + partial + minor response. Complete response was defined as no evidence of measurable disease for a minimum of 4 weeks. Partial response was defined as a ≥ 50% decrease in the sum of the products of the dimensions of all measurable lesions for at least 1 month. Minor response was defined as 25-50% decrease in the sum of the products of the dimensions of all measurable lesions for at least 1 month; Symbols: + combination treatment; change treatment