Table 1: A, avelumab; M, mitotane; E, etoposide; D,
doxorubicin; C, cisplatin; Sz, streptozotocin; V, vincristine, NA: not
available; a: Complete + partial response until
progressive disease or death; b: Complete + partial
response. Complete response was defined as the disappearance of all
clinical evidence of the tumor on physical examination or on radiography
and the complete recalcification of all osteolytic metastases for a
minimum of 4 weeks. Partial response required at least a 50% decrease
in the measurable tumor size and ≥ 50% recalcification of osteolytic
metastases for at least 4 weeks without the appearance of new lesions;c: first-line therapy: M+E+D+C or M+Sz; second-line
therapy: M+E+D+CM+Sz or M+SzM+E+D+C; d: Complete +
partial response. Complete response was defined as the disappearance of
all clinical evidence of the tumor for a minimum of 4 weeks. Partial
response required ≥ 50% decrease in the sum of the products of the
perpendicular diameters of measured lesions or a decrease ≥ 30% in the
sum of liver measurements below the costal margins in the right, left,
and xiphoid lines for a minimum of 4 weeks.; e:
Mitotane was employed after disease progression following cisplatin and
etoposide treatment in patients who had not received prior mitotane
treatment; f: Complete + partial response. Complete
response was defined as the disappearance of all clinical evidence of
the tumor on at least two successive evaluations. Partial response
required a ≥ 50% decrease in the sum of the products of the
perpendicular dimensions of all measurable lesions on at least 2
evaluations; g: Complete + partial + minor response.
Complete response was defined as no evidence of measurable disease for a
minimum of 4 weeks. Partial response was defined as a ≥ 50% decrease in
the sum of the products of the dimensions of all measurable lesions for
at least 1 month. Minor response was defined as 25-50% decrease in the
sum of the products of the dimensions of all measurable lesions for at
least 1 month; Symbols: + combination treatment; change treatment