Stratified analyses by pre-defined thresholds
We evaluated the sensitivity and specificity of the data at cut-off
values commonly used as 95% PPV. For peanut SPT ≥ 8mm, sIgE peanut ≥ 15
kUA /L and Ara h 2 ≥ 0.35 kUA /L are all
highly specific (≥ 90 %) with results at or over those values ruling in
food allergy. For HE allergy (both raw and cooked HE) an Ovomucoid ≥
0.35 kUA/L was highly specific (≥ 90 %) and when
positive rules in food allergy. For CMA, SPT ≥ 8mm, was highly specific
(≥ 90 %). We were unable to calculate sIgE CM ≥15 kUA/L as the Bivariate binomial model failed to converge due to over
dispersed parameter along with limited number of studies. Cor a 14 was
highly specific for hazelnut allergy and with values ≥ 0.35
kUA /L can rule in food allergy. More information is
available in Table 5.