Conclusions
There is strong evidence supporting the accuracy of SPT, sIgE, and CRD to support the diagnosis of peanut, CM, HE, and tree nut allergies and of BAT to support the diagnosis of peanut and sesame allergies, in patients with suggestive clinical history of IgE-mediated reactions. However, for other foods such as soy, sesame, wheat, and shrimp, the evidence is not as robust. Further research is needed to evaluate the usefulness of combining existing diagnostic tests and to assess novel diagnostic techniques to minimize the need for OFCs.
The upcoming FA diagnostic guidelines from EAACI will incorporate the findings of this review, along with expert opinions and other evidence, to provide practical recommendations for best practice to diagnose IgE-mediated food allergy.