6-1. Clinical presentation
There are multiple case reports and studies of immediate type HSRs to PPIs, ranging from mild to severe reactions, that generally occur within a few hours after the last drug dose.21,37-44Approximately, half of the immediate HSRs to PPI were anaphylaxis, with a prevalence varying between 9.1 and 69.0%, while urticaria and/or angioedema have been reported with a percentage of 26.2%–90.9%14,15,19,23,28,45-47. Dyspnea, pruritus, nausea, vomiting, diarrhea and rhinitis have also been reported.17,28