7-2. c. Provocation tests in non-immediate hypersensitivity to
PPIs
The value of DPT with PPIs for delayed T cell-mediated reactions is
unknown. Delayed T cell-mediated reactions after PPI intake are rare.
For delayed reactions to PPI, the clinical history together with patch
testing is generally considered sufficient to detect PPI delayed
hypersensitivity.28 We do not know of any study
evaluating the role of the DPT in PPI delayed hypersensitivity. However,
we do recommend DPT in case of a doubtful history and negative skin test
results in non-severe delayed reactions in order to exclude PPI
hypersensitivity as a 100% sensitivity cannot be assumed.