6.3.b. Tolerance
Current data highlight the importance of a thorough allergy work-up to
find safe alternative PPIs. Because of the high cross-reactivity rates
among PPIs (Table 5), a safe alternative PPI should only be recommended
after a complete drug allergy work-up (iskin testing followed by DPT in
case of negative results). The PPI to be tested as a safe alternative,
may be selected according to the cross-reactivity rates reported in the
literature and listed in table 6).