Materials and Methods
Our study is a cross-sectional, case-control study. The local ethical
committee approved this study. Patients between the ages of 18 and 50
admitted to the emergency department with hypoglycemia symptoms and
whose blood glucose was 70 and below were included in the study. The
fasting routine blood samples were investigated by examining these
patients’ internal medicine-endocrinology department records after their
emergency room administration. Hypoglycemia patients whose cardiology
application was recommended mainly due to palpitation symptoms,
dizziness, and presyncope, were evaluated in terms of essential
echocardiographic evaluation, tissue doppler, and flow-mediated
dilatation.
Patients diagnosed with diabetes mellitus, hypertension, hyperlipidemia,
coronary artery disease, congestive heart failure, peripheral artery
disease, moderate to severe heart valve disease, cardiomyopathies,
thyroid dysfunction, chronic obstructive pulmonary disease, malignancy,
rheumatological disease, active infection, kidney failure, liver
disease, obesity (body mass index >30), drug
usage(including beta-blockers), and patients with heavy alcohol intake
and smoking were excluded from the study. A total of 46 patients were
included in the survey by excluding patients with low echogenicity who
were not suitable for imaging. Thirty healthy individuals who were not
diagnosed with hypoglycemia before were included in the study as the
control group.
The HOMA-IR is being used extensively for estimates of beta-cell
function and insulin resistance and calculated with the formula
’(Fasting insulin in mIU/L * fasting blood glucose in mg/dL) / 405’. A
HOMA-IR value of 2.5 and above was accepted as insulin resistance (21).
The groups with and without insulin resistance were determined based on
the HOMA-IR scores of the patient group, and it was evaluated whether
the differences with the control group were related to insulin
resistance.