Identification of protein targets using PharmMapper
For identifying the protein targets of the thalidomide, we utilized the PharmMapper server (http://www.lilab-ecust.cn/pharmmapper/)32. The server identifies possible physiological protein targets of any drug molecule by using a pharmacophore-based mapping approach. The three-dimensional structure of thalidomide was obtained from PubChem and processed on the PharmMapper server choosing only human protein target sets. The top 100 target proteins were selected based on the ranking associated with a fit score (pKd value) for further enrichment analysis using Enrichr29.