Data Collection
A total of 16 gene expression datasets including 15 publicly available
expression datasets were meta-analyzed in this study. Transcriptomes of
SARS-coV-2 infected lung tissues matched with healthy control and
SARS-coV-2 treated A549 cells were obtained from GEO (Accession ID:
GSE147507) 16. Transcriptome data of bronchoalveolar
lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) were
obtained from BIG Data Center (https://bigd.big.ac.cn/) (Accession
ID: CRA002390) 17. The expression profiles of systemic
lupus erythematosus (Accession ID: GSE112087) 18, bone
marrow cells treated with lenalidomide (Accession ID: GSE106748)19, lymphoma cells treated with lenalidomide
(Accession ID: GSE60618) 20 , CD34 positive cells
treated with pomalidomide (Accession ID: GSE144052), MERS infected PBMC
(Accession: GSE1739) 21, lenalidomide treated PBMC
(Accession ID: GSE84251) and CC-122 treated lymphoma cells (Accession
ID: GSE75420) 22 were procured from GEO and
differentially expressed genes (DEG) were identified using limma23. Library of Integrated Network-Based Cellular
Signatures (iLINCS) is a database which contains the gene expression
signatures of more than 21,000 compounds
(http://www.ilincs.org/ilincs/). We obtained the gene expression
signatures for A549 cells treated with 10µM thalidomide for 6h
(LINCSCP_4683) and 24h (LINCSCP_4463), 100 µM lenalidomide for 6h
(LINCSCP_4650) and 24h (LINCSCP_4427).