Identification of protein targets using PharmMapper
For identifying the protein targets of the thalidomide, we utilized the
PharmMapper server (http://www.lilab-ecust.cn/pharmmapper/)32. The server identifies possible physiological
protein targets of any drug molecule by using a pharmacophore-based
mapping approach. The three-dimensional structure of thalidomide was
obtained from PubChem and processed on the PharmMapper server choosing
only human protein target sets. The top 100 target proteins were
selected based on the ranking associated with a fit score (pKd value)
for further enrichment analysis using Enrichr29.