Data Collection
A total of 16 gene expression datasets including 15 publicly available expression datasets were meta-analyzed in this study. Transcriptomes of SARS-coV-2 infected lung tissues matched with healthy control and SARS-coV-2 treated A549 cells were obtained from GEO (Accession ID: GSE147507) 16. Transcriptome data of bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) were obtained from BIG Data Center (https://bigd.big.ac.cn/) (Accession ID: CRA002390) 17. The expression profiles of systemic lupus erythematosus (Accession ID: GSE112087) 18, bone marrow cells treated with lenalidomide (Accession ID: GSE106748)19, lymphoma cells treated with lenalidomide (Accession ID: GSE60618) 20 , CD34 positive cells treated with pomalidomide (Accession ID: GSE144052), MERS infected PBMC (Accession: GSE1739) 21, lenalidomide treated PBMC (Accession ID: GSE84251) and CC-122 treated lymphoma cells (Accession ID: GSE75420) 22 were procured from GEO and differentially expressed genes (DEG) were identified using limma23. Library of Integrated Network-Based Cellular Signatures (iLINCS) is a database which contains the gene expression signatures of more than 21,000 compounds (http://www.ilincs.org/ilincs/). We obtained the gene expression signatures for A549 cells treated with 10µM thalidomide for 6h (LINCSCP_4683) and 24h (LINCSCP_4463), 100 µM lenalidomide for 6h (LINCSCP_4650) and 24h (LINCSCP_4427).