REFERENCES
1. Doll R.J., Joseph N.I., McGarry D., Jhaveri D., Sher T., R. H. Epidemiology of Allergic Diseases. . In: M M, editor. Allergy and Asthma. Cham: Springer; 2019.
2. Gilles S, Akdis C, Lauener R, et al. The role of environmental factors in allergy: A critical reappraisal. Exp Dermatol2018;27 :1193-1200.
3. Intergovernmental panel on climate change. Climate Change 2013: The Physical Science Basis. Available from: https://www.ipcc.ch/site/assets/uploads/2018/03/WG1AR5_SummaryVolume_FINAL.pdf. Accessed May 15, 2020
4. Harun NS, Lachapelle P, Douglass J. Thunderstorm-triggered asthma: what we know so far. J Asthma Allergy 2019;12 :101-108.
5. Woodhead M. Hospitals overwhelmed with patients after ”thunderstorm asthma” hits Melbourne. BMJ 2016;355 :i6391.
6. D’Amato G, Vitale C, D’Amato M, et al. Thunderstorm-related asthma: what happens and why. Clin Exp Allergy 2016;46 :390-396.
7. James KA, Strand M, Hamer MK, Cicutto L. Health Services Utilization in Asthma Exacerbations and PM10 Levels in Rural Colorado. Ann Am Thorac Soc 2018;15 :947-954.
8. Reid CE, Jerrett M, Tager IB, Petersen ML, Mann JK, Balmes JR. Differential respiratory health effects from the 2008 northern California wildfires: A spatiotemporal approach. Environ Res2016;150 :227-235.
9. Prunicki MM, Dant CC, Cao S, et al. Immunologic effects of forest fire exposure show increases in IL-1beta and CRP. Allergy 2020. DOI: 10.1111/all.14251.
10. Donovan BM, Bastarache L, Turi KN, Zutter MM, Hartert TV. The current state of omics technologies in the clinical management of asthma and allergic diseases. Ann Allergy Asthma Immunol2019;123 :550-557.
11. Buenrostro JD, Wu B, Chang HY, Greenleaf WJ. ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. Curr Protoc Mol Biol 2015;109 :21 29 21-21 29 29.
12. Schwartzman O, Tanay A. Single-cell epigenomics: techniques and emerging applications. Nat Rev Genet 2015;16 :716-726.
13. Cheung P, Vallania F, Warsinske HC, et al. Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging. Cell 2018;173 :1385-1397 e1314.
14. Forno E, Wang T, Qi C, et al. DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study. Lancet Respir Med 2019;7 :336-346.
15. United States Enviromental Protectiion Agency. Criteria Air Pollutants. 2017 Available from: https://www.epa.gov/criteria-air-pollutants#self. Accessed May 15, 2020
16. World Health Organization. Ambient air pollution: Pollutants. 2020 Available from: https://www.who.int/airpollution/ambient/pollutants/en/. Accessed May 15, 2020
17. Morgenstern V, Zutavern A, Cyrys J, et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med 2008;177 :1331-1337.
18. Kramer U, Sugiri D, Ranft U, et al. Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas. J Dermatol Sci 2009;56 :99-105.
19. Ohlwein S, Kappeler R, Kutlar Joss M, Kunzli N, Hoffmann B. Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence. Int J Public Health2019;64 :547-559.
20. Li Q, Yi Q, Tang L, et al. Influence of Ultrafine Particles Exposure on Asthma Exacerbation in Children: A Meta-Analysis. Curr Drug Targets 2019;20 :412-420.
21. Achakulwisut P, Brauer M, Hystad P, Anenberg SC. Global, national, and urban burdens of paediatric asthma incidence attributable to ambient NO2 pollution: estimates from global datasets. Lancet Planet Health 2019;3 :e166-e178.
22. Norbäck D, Lu C, Zhang Y, et al. Sources of indoor particulate matter (PM) and outdoor air pollution in China in relation to asthma, wheeze, rhinitis and eczema among pre-school children: Synergistic effects between antibiotics use and PM10 and second hand smoke.Environment international 2019;125 :252-260.
23. Penard-Morand C, Raherison C, Charpin D, et al. Long-term exposure to close-proximity air pollution and asthma and allergies in urban children. Eur Respir J 2010;36 :33-40.
24. Samoli E, Nastos PT, Paliatsos AG, Katsouyanni K, Priftis KN. Acute effects of air pollution on pediatric asthma exacerbation: evidence of association and effect modification. Environ Res2011;111 :418-424.
25. Zhao Y, Hu J, Tan Z, et al. Ambient carbon monoxide and increased risk of daily hospital outpatient visits for respiratory diseases in Dongguan, China. Sci Total Environ 2019;668 :254-260.
26. Kim J, Han Y, Seo SC, et al. Association of carbon monoxide levels with allergic diseases in children. Allergy Asthma Proc2016;37 :e1-7.
27. Xiao Q, Liu Y, Mulholland JA, et al. Pediatric emergency department visits and ambient Air pollution in the U.S. State of Georgia: a case-crossover study. Environ Health 2016;15 :115.
28. To T, Zhu J, Stieb D, et al. Early life exposure to air pollution and incidence of childhood asthma, allergic rhinitis and eczema.Eur Respir J 2020;55 .
29. Rage E, Jacquemin B, Nadif R, et al. Total serum IgE levels are associated with ambient ozone concentration in asthmatic adults.Allergy 2009;64 :40-46.
30. Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br J Dermatol 2005;153 :1096-1100.
31. Brandt EB, Biagini Myers JM, Acciani TH, et al. Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility. J Allergy Clin Immunol 2015;136 :295-303 e297.
32. Munoz X, Barreiro E, Bustamante V, Lopez-Campos JL, Gonzalez-Barcala FJ, Cruz MJ. Diesel exhausts particles: Their role in increasing the incidence of asthma. Reviewing the evidence of a causal link. Sci Total Environ 2019;652 :1129-1138.
33. Naclerio R, Ansotegui IJ, Bousquet J, et al. International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients with AR: Current knowledge and future strategies. World Allergy Organ J2020;13 :100106.
34. Xian M, Ma S, Wang K, et al. Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells.Allergy Asthma Immunol Res 2020;12 :56-71.
35. Lee MK, Xu CJ, Carnes MU, et al. Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults. Clin Epigenetics 2019;11 :37.
36. Prunicki M, Stell L, Dinakarpandian D, et al. Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma.Clin Epigenetics 2018;10 :2.
37. Zhao F, Durner J, Winkler JB, et al. Pollen of common ragweed (Ambrosia artemisiifolia L.): Illumina-based de novo sequencing and differential transcript expression upon elevated NO(2)/O(3).Environ Pollut 2017;224 :503-514.
38. Zhao F, Elkelish A, Durner J, et al. Common ragweed (Ambrosia artemisiifolia L.): allergenicity and molecular characterization of pollen after plant exposure to elevated NO2. Plant Cell Environ2016;39 :147-164.
39. El Kelish A, Zhao F, Heller W, et al. Ragweed (Ambrosia artemisiifolia) pollen allergenicity: SuperSAGE transcriptomic analysis upon elevated CO2 and drought stress. BMC Plant Biol2014;14 :176.
40. Burke H, Leonardi-Bee J, Hashim A, et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis. Pediatrics 2012;129 :735-744.
41. Thacher JD, Gruzieva O, Pershagen G, et al. Parental smoking and development of allergic sensitization from birth to adolescence.Allergy 2016;71 :239-248.
42. Chao MR, Cooke MS, Kuo CY, et al. Children are particularly vulnerable to environmental tobacco smoke exposure: Evidence from biomarkers of tobacco-specific nitrosamines, and oxidative stress.Environ Int 2018;120 :238-245.
43. Nakamura Y, Miyata M, Ohba T, et al. Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H)2-type immune responses and airway inflammation. J Allergy Clin Immunol2008;122 :1208-1214.
44. Kearley J, Silver JS, Sanden C, et al. Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection. Immunity2015;42 :566-579.
45. Strzelak A, Ratajczak A, Adamiec A, Feleszko W. Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review. Int J Environ Res Public Health 2018;15 .
46. Nishida K, Brune KA, Putcha N, et al. Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension. Am J Physiol Lung Cell Mol Physiol2017;313 :L581-L591.
47. Gilpin DF, McGown KA, Gallagher K, et al. Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens. Respir Res 2019;20 :267.
48. Peroni DG, Nuzzi G, Trambusti I, Di Cicco ME, Comberiati P. Microbiome Composition and Its Impact on the Development of Allergic Diseases. Front Immunol 2020;11 :700.
49. Borbet TC, Zhang X, Muller A, Blaser MJ. The role of the changing human microbiome in the asthma pandemic. J Allergy Clin Immunol2019;144 :1457-1466.
50. Ranjan R, Rani A, Metwally A, McGee HS, Perkins DL. Analysis of the microbiome: Advantages of whole genome shotgun versus 16S amplicon sequencing. Biochem Biophys Res Commun 2016;469 :967-977.
51. Reiger M, Traidl-Hoffmann C, Neumann AU. The skin microbiome as a clinical biomarker in atopic eczema: Promises, navigation, and pitfalls.J Allergy Clin Immunol 2020;145 :93-96.
52. Feehley T, Plunkett CH, Bao R, et al. Healthy infants harbor intestinal bacteria that protect against food allergy. Nat Med2019;25 :448-453.
53. Cukrowska B, Bierla JB, Zakrzewska M, Klukowski M, Maciorkowska E. The Relationship between the Infant Gut Microbiota and Allergy. The Role of Bifidobacterium breve and Prebiotic Oligosaccharides in the Activation of Anti-Allergic Mechanisms in Early Life. Nutrients2020;12 .
54. Arrieta MC, Stiemsma LT, Dimitriu PA, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med 2015;7 :307ra152.
55. Lipsky ZW, Marques CNH, German GK. Lipid depletion enables permeation of Staphylococcus aureus bacteria through human stratum corneum. Tissue Barriers 2020:1754706.
56. Altunbulakli C, Reiger M, Neumann AU, et al. Relations between epidermal barrier dysregulation and Staphylococcus species-dominated microbiome dysbiosis in patients with atopic dermatitis. J Allergy Clin Immunol 2018;142 :1643-1647 e1612.
57. Nakatsuji T, Chen TH, Two AM, et al. Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression. J Invest Dermatol 2016;136 :2192-2200.
58. Lee SH, Gong YN, Ryoo E. Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases.Korean J Pediatr 2017;60 :145-150.
59. Mohajeri MH, Brummer RJM, Rastall RA, et al. The role of the microbiome for human health: from basic science to clinical applications. Eur J Nutr 2018;57 :1-14.
60. Gardner KG, Gebretsadik T, Hartman TJ, et al. Prenatal Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Childhood Atopic Dermatitis.J Allergy Clin Immunol Pract 2020;8 :937-944.
61. Vahdaninia M, Mackenzie H, Dean T, Helps S. omega-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: A systematic review and meta-analysis.Ann Allergy Asthma Immunol 2019;122 :302-313 e302.
62. Rosa MJ, Hartman TJ, Adgent M, et al. Prenatal polyunsaturated fatty acids and child asthma: Effect modification by maternal asthma and child sex. J Allergy Clin Immunol 2020;145 :800-807 e804.
63. Papamichael MM, Shrestha SK, Itsiopoulos C, Erbas B. The role of fish intake on asthma in children: A meta-analysis of observational studies. Pediatr Allergy Immunol 2018;29 :350-360.
64. Camargo CA, Jr., Clark S, Kaplan MS, Lieberman P, Wood RA. Regional differences in EpiPen prescriptions in the United States: the potential role of vitamin D. J Allergy Clin Immunol2007;120 :131-136.
65. Mullins RJ, Clark S, Camargo CA, Jr. Regional variation in epinephrine autoinjector prescriptions in Australia: more evidence for the vitamin D-anaphylaxis hypothesis. Ann Allergy Asthma Immunol2009;103 :488-495.
66. Allen KJ, Koplin JJ, Ponsonby AL, et al. Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol 2013;131 :1109-1116, 1116 e1101-1106.
67. Mohammadzadeh I, Darvish S, Qujeq D, Hajiahmadi M, Vaghari-Tabari M. Association of serum 25-OH vitamin D(3) with serum IgE and the Pediatric Asthma Severity Score in patients with pediatric asthma. Allergy Asthma Proc 2020;41 :126-133.
68. Borlee F, Yzermans CJ, Krop EJM, et al. Residential proximity to livestock farms is associated with a lower prevalence of atopy.Occup Environ Med 2018;75 :453-460.
69. Levin ME, Botha M, Basera W, et al. Environmental factors associated with allergy in urban and rural children from the South African Food Allergy (SAFFA) cohort. J Allergy Clin Immunol2020;145 :415-426.
70. Marrs T, Logan K, Craven J, et al. Dog ownership at three months of age is associated with protection against food allergy. Allergy2019;74 :2212-2219.
71. Kim HJ, Lee SH, Hong SJ. Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids. Allergy Asthma Immunol Res 2020;12 :137-148.
72. Zven SE, Susi A, Mitre E, Nylund CM. Association Between Use of Multiple Classes of IAntibiotic in Infancy and Allergic Disease in Childhood. JAMA Pediatr. 2019;174 (2):199-200.
73. Mitre E, Susi A, Kropp LE, Schwartz DJ, Gorman GH, Nylund CM. Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood. JAMA Pediatr 2018;172 :e180315.
74. O’Mahony L. Short Chain Fatty Acids Modulate Mast Cell Activation.Allergy 2020.
75. Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A2010;107 :11971-11975.
76. Stokholm J, Thorsen J, Chawes BL, et al. Cesarean section changes neonatal gut colonization. J Allergy Clin Immunol2016;138 :881-889 e882.
77. Higgins D, Karmaus W, Jiang Y, Banerjee P, Sulaiman IM, Arshad HS. Infant wheezing and prenatal antibiotic exposure and mode of delivery: a prospective birth cohort study. J Asthma 2020:1-12.
78. Sandall J, Tribe RM, Avery L, et al. Short-term and long-term effects of caesarean section on the health of women and children.Lancet 2018;392 :1349-1357.
79. Keag OE, Norman JE, Stock SJ. Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis. PLoS Med2018;15 :e1002494.
80. Strachan DP. Hay fever, hygiene, and household size. BMJ1989;299 :1259-1260.
81. Gupta RS, Walkner MM, Greenhawt M, et al. Food Allergy Sensitization and Presentation in Siblings of Food Allergic Children. J Allergy Clin Immunol Pract 2016;4 :956-962.
82. Brew BK, Lundholm C, Viktorin A, Lichtenstein P, Larsson H, Almqvist C. Longitudinal depression or anxiety in mothers and offspring asthma: a Swedish population-based study. Int J Epidemiol2018;47 :166-174.
83. Smejda K, Polanska K, Merecz-Kot D, et al. Maternal Stress During Pregnancy and Allergic Diseases in Children During the First Year of Life. Respir Care 2018;63 :70-76.
84. Magnus MC, Wright RJ, Roysamb E, et al. Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring. Am J Epidemiol 2018;187 :1199-1209.
85. Flanigan C, Sheikh A, DunnGalvin A, Brew BK, Almqvist C, Nwaru BI. Prenatal maternal psychosocial stress and offspring’s asthma and allergic disease: A systematic review and meta-analysis. Clin Exp Allergy 2018;48 :403-414.
86. Rosa MJ, Lee AG, Wright RJ. Evidence establishing a link between prenatal and early-life stress and asthma development. Curr Opin Allergy Clin Immunol 2018;18 :148-158.
87. Chan CWH, Law BMH, Liu YH, et al. The Association between Maternal Stress and Childhood Eczema: A Systematic Review. Int J Environ Res Public Health 2018;15 .
88. Braig S, Weiss JM, Stalder T, Kirschbaum C, Rothenbacher D, Genuneit J. Maternal prenatal stress and child atopic dermatitis up to age 2 years: The Ulm SPATZ health study. Pediatr Allergy Immunol2017;28 :144-151.
89. Herberth G, Roder S, Bockelbrink A, et al. Stressful life events in childhood and allergic sensitization. Allergol Select2018;2 :1-9.
90. Patterson AM, Yildiz VO, Klatt MD, Malarkey WB. Perceived stress predicts allergy flares. Ann Allergy Asthma Immunol2014;112 :317-321.
91. Marshall GD, Tull MT. Stress, mindfulness, and the allergic patient.Expert Rev Clin Immunol 2018;14 :1065-1079.
92. Harter K, Hammel G, Krabiell L, et al. Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study. Int Arch Allergy Immunol 2019;179 :262-272.
93. Ronnstad ATM, Halling-Overgaard AS, Hamann CR, Skov L, Egeberg A, Thyssen JP. Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: A systematic review and meta-analysis. J Am Acad Dermatol 2018;79 :448-456 e430.
94. Ver Heul A, Planer J, Kau AL. The Human Microbiota and Asthma.Clin Rev Allergy Immunol 2019;57 :350-363.
95. Stiemsma LT, Turvey SE. Asthma and the microbiome: defining the critical window in early life. Allergy Asthma Clin Immunol2017;13 :3.
96. Korpela K, Salonen A, Vepsalainen O, et al. Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants. Microbiome2018;6 :182.
97. Salameh M, Burney Z, Mhaimeed N, et al. The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis. Scand J Immunol 2020;91 :e12855.
98. Turcanu V, Brough HA, Du Toit G, et al. Immune mechanisms of food allergy and its prevention by early intervention. Curr Opin Immunol 2017;48 :92-98.
99. Baker MG, Nowak-Wegrzyn A. Food allergy prevention: current evidence. Curr Opin Clin Nutr Metab Care2020;23 :196-202.
100. Brough HA, Nadeau KC, Sindher SB, et al. Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented? Allergy 2020. DOI: 10.1111/all.14304.
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