Epithelial Cells Infected:
The number of epithelial target cells, T , that are infected
(cells/mL) by virus. This metric summarizes the damage to host lung
epithelial host cells during the course of infection, and is considered
a proxy for the degree of pulmonary inflammatory response and lung
tissue damage, and hence pulmonary clinical signs and symptoms within an
individual patient. There is increasing evidence that other tissues and
organs may be infected by SARS-CoV-2, but those are out-of-scope for
this model.
These endpoints were compared to the reference case of the natural
history, and expressed as the metric:
log10( Treatment Metric / No-Treatment Metric )
Therefore, a difference of 1 unit of a metric between two treatments
indicates an order-of-magnitude change (i.e. a decibel scale).
The 1, 2, 3 target interventions with the best metric at each treatment
initiation time, endpoint and summed drug effect was tabulated. Other
treatments within 5% of the optimal treatment were also reported and
sorted by metric quality.