Conclusions
The simulation work presented here leverages the known kinetics of the SARS-CoV-2 life cycle to rank potential targeted approaches with a focus on the likely need to combine repurposed, low-potency agents. These simulations suggest early intervention is critical and targeting multiple points important to viral replication within and release from infected host cells is a good strategy for reducing both viral load and host cell infection. In addition, we observed that the time-window opportunity for a therapeutic intervention to effect duration of viral shedding exceeds the effect on sparing epithelial cells from infection or impact on viral load AUC. Furthermore, the impact on reduction on duration of shedding may extend further in patients who exhibit a prolonged shedder phenotype.