In December 2019, a novel coronavirus (Sars-CoV-2 ) emerged from Wuhan, Hubei province, China, and has spread worldwide, with more than 4 million confirmed cases[1,2,3]. Available literature on the clinical characteristics and natural history of pediatric patients infected with Sars-CoV-2 is limited and less has been established regarding guidelines for the treatment of immunocompromised pediatric patients. This is a case report on the clinical course and management of a 6 year old female with acute lymphoblastic lymphoma with Sars-CoV-2. The goal is to highlight the need for management guidelines in the care of pediatric cancer patients with Sars-CoV-2.