Legends:
Fig 1 PRISMA diagram (study flow diagram for evidence source and selection)
Fig 2 Change in certainty of evidence (CoE) in original and updated Cochrane systematic review. A) across all categories of CoE as characterized by GRADE; b) grouped as very low/low vs moderate/high quality evidence
Fig 3 Comparison of effects of health interventions in meta-analyses in which certainty of evidence (CoE) changed from very low/low to moderate/high vs effects in meta-analyses where CoE changed from moderate/high to very low/low (a); b) summary of studies shown in a) with addition of comparison of meta-analyses where CoE did not change. Abbreviations; ROR-ratio of odds ratio; τ2(tau2) statistic and H2 – measures of heterogeneity; I 2 statistic- measure of inconsistency.
Fig 4. a) Absolute deviation (AD) of treatment effects (aROR) in meta-analyses in which certainty of evidence (CoE) changed from very low/low to moderate/high vs effects in meta-analyses where CoE changed from moderate/high to very low/low; b) summary of aROR by change in CoE [For graph displaying aROR for all studies, including those that did not have change in CoE, see Appendix, App Fig 4 and App 4a]
Fig 5 Change in effect size, qualitative analysis (see also App Figs 12 and 13).