Condensed Abstract
A novel conductive hydrogel was developed as a method to treat substrate-based arrhythmias by homogenizing conduction through disrupted myocardium. In ex vivo canine hearts, the hydrogel was injected evenly through ablated regions of myocardium. Electroanatomic activation mapping of the epicardial surface demonstrated a shift in conduction to surround edges following ablation of the region. Following injection of the conductive hydrogel, conduction improved through the ablated region approximating baseline in all 4 hearts. This proof-of-concept study demonstrates that conductive hydrogel can be injected into acutely disrupted myocardium to restore conduction.