Potential Impact of Brain and Heart Interaction on Cardiovascular System
in COVID-19 Patients
Abstract
Abstract: Coronavirus disease 2019 (COVID-19), has affected many regions
and countries. It is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), which has a powerful ability to spread and
is highly lethal. SARS-CoV-2 belongs to CoVs, together with the SARS-CoV
and middle east respiratory syndrome-CoV. SARS-CoV-2 damages the lungs
and some other organs in humans by infecting cells via binding to the
ACE2 receptor. The infection with SARS-CoV-2 results in varying degrees
of clinical manifestations. Although the amount of the evidence in favor
of the impact of COVID-19 on the clinical manifestations of myocardial
injury and the onset of cardiovascular disease (CVD) is increasing,
myocardial cell damage caused by viruses not identified in biopsies and
autopsies. Therefore, it has been suggested that viruses might affect
cardiac function by mechanisms other than direct infection of
cardiomyocytes, and several plausible conjectures have been proposed.
Based on the fact that the viruses can exert influence on multiple
systems in an organism, this article describes and proposes, for the
first time, the possible impact of the interaction between the brain and
the heart on the cardiovascular system in COVID-19 patients.