b) correlation with functional MRI outcomes
We reanalyzed the correlation of functional MRI and LCI in 14 children
with CF. The extent of QDP ranged between 15% and 35% (Figure 2) The
correlation between QDP and LCI remained consistently strong in both
Spiroware versions (3.2.1: rS=0.66, p=0.03; 3.3.1:
rS=0.69 p=0.02). The increase in LCI per increase in
ventilation defect was comparable for both Spiroware versions (Spiroware
3.2.1: 1.28 LCI units/percent perfusion defect (95% CI 0.67; 1.89);
Spiroware 3.3.1: 1.32 LCI units/percent perfusion defect (95% CI 0.55;
2.10); Supplemental Figure 3).