4.3 Strengths and weaknesses of this study
We performed a thorough reanalysis of clinical and research MBW data
using the corrected algorithm incorporated in Spiroware 3.3.1, with data
originally collected or reloaded in Spiroware 3.2.123. We performed rigorous quality control with only
perfect data being used 15 which minimizes bias due to
sampling variation. Further, we were able to use a wide range of
different datasets obtained in a clinical routine setting or from
clinical studies to assess the impact of measurement correction on
various clinimetric properties of LCI. By nature, the main limitation
lies in the retrospective application of the correction.