Summary/Key points
-The
clinical profile of LPR patients may vary regarding the occurrence of
OSAS. The presence of OSAS in LPR patients may result with fewer
LPR-related symptoms, while LPR patients without OSAS had a higher
number of HREs than patients with LPR and OSAS. Moreover, OSAS patients
has a lower proportion of hiatal hernia and esophagitis than classical
LPR patients.
-The occurrence of HREs in the evening was associated with a more severe
ESS; the severity of subjective OSAS symptoms being associated with the
severity of LPR according to RSS quality of life score.
-Patients with OSAS, LPR and GERD had higher number of nocturnal HREs
compared with those without GERD but there was no temporal relationship
between nocturnal HRE and the occurrence of awakenings/arousals.
References :
1. Lechien JR, Akst LM, Hamdan AL, et al. Evaluation and Management of
Laryngopharyngeal Reflux Disease: State of the Art Review.Otolaryngol-Head Neck Surg . 2019;160(5):762-782.
doi:10.1177/0194599819827488.
2. Doo JG, Kim SI, Park JM, Kwon OE, Lee YC, Eun YG.
Changes in Pharyngeal
Baseline Impedance in Patients With Laryngopharyngeal Reflux.Otolaryngol Head Neck Surg . 2020; 163(3):563-568. doi:
10.1177/0194599820918820.
3. Lechien JR, Muls V, Dapri G, Mouawad F, Eisendrath P, Schindler A,
Nacci A, Barillari MR, Finck C, Saussez S, Akst LM, Sataloff RT.
The management of
suspected or confirmed laryngopharyngeal reflux patients with
recalcitrant symptoms: A contemporary review. Clin Otolaryngol .
2019; 44(5):784-800. doi: 10.1111/coa.13395.
4. Lechien JR, Bobin F, Dapri G, Eisendrath P, Salem C, Mouawad F, Horoi
M, Thill MP, Dequanter D, Rodriguez A, Muls V, Saussez S.
Hypopharyngeal-Esophageal
Impedance-pH Monitoring Profiles of Laryngopharyngeal Reflux Patients.Laryngoscope . 2020. doi: 10.1002/lary.28736.
5. Gouveia CJ, Yalamanchili A, Ghadersohi S, Price CPE, Bove M, Attarian
HP, Tan BK. Are chronic
cough and laryngopharyngeal reflux more common in obstructive sleep
apnea patients? Laryngoscope . 2019; 129(5):1244-1249. doi:
10.1002/lary.27557.
6. Laohasiriwong S,
Johnston N, Woodson BT. Extra-esophageal reflux, NOSE score, and sleep
quality in an adult clinic population. Laryngoscope. 2013;
123(12):3233-8. doi: 10.1002/lary.24236.
7. Teklu M, Gouveia CJ, Yalamanchili A, Ghadersohi S, Price CPE, Bove M,
Attarian HP, Tan BK.
Predicting
Obstructive Sleep Apnea Status With the Reflux Symptom Index in
a Sleep Study Population. Laryngoscope . 2020. doi:
10.1002/lary.28592.
8. Lechien JR, Finck C, Huet K, Khalife M, Fourneau AF, Delvaux V,
Piccaluga M, Harmegnies B, Saussez S.
Impact of age on
laryngopharyngeal reflux disease presentation: a multi-center
prospective study. Eur Arch Otorhinolaryngol . 2017;
274(10):3687-3696.
9. Lechien JR, Bobin F, Muls V, Thill MP, Horoi M, Ostermann K, Huet K,
et al. Validity and
reliability of the reflux symptom score. Laryngoscope . 2019.
doi: 10.1002/lary.28017.
10. Hoppo T, Sanz AF, Nason KS, et al.
How much pharyngeal
exposure is ”normal”? Normative data for laryngopharyngeal reflux events
using hypopharyngeal multichannel intraluminal impedance (HMII).J Gastrointest Surg . 2012; 16(1):16-24; discussion 24-5.
11. Kaminska M, Jobin V, Mayer P, Amyot R, Perraton-Brillon M, Bellemare
F.
The Epworth Sleepiness Scale:
self-administration versus administration by the physician,
and validation of a French version. Can Respir J . 2010;
17(2):e27-34. doi: 10.1155/2010/438676.
12. Pichot P, Brun JP.
Brief self-evaluation
questionnaire for depressive, asthenic and anxious dimensions.Ann Med Psychol (Paris) . 1984; 142(6):862-5.
13.
Sher
AE, Schechtman
KB, Piccirillo
JF. The efficacy of surgical modifications of the upper airway in
adults with obstructive sleep apnea syndrome. Sleep . 1996;
19(2):156-77.
14. Elhennawi DM, Ahmed MR, Abou-Halawa AS.
Correlation of
obstructive sleep apnoea and laryngopharyngeal reflux: phmetry study.Clin Otolaryngol . 2016; 41(6):758-761. doi: 10.1111/coa.12640.
15. Xiao YL, Liu FQ, Li J, Lv JT, Lin JK, Wen WP, Chen MH.
Gastroesophageal
and laryngopharyngeal reflux profiles in patients with
obstructive sleep apnea/hypopnea syndrome as determined by combined
multichannel intraluminal impedance-pH monitoring.Neurogastroenterol Motil . 2012; 24(6):e258-65. doi:
10.1111/j.1365-2982.2012.01920.x.
16. Ermis F, Akyuz F, Arici S, Uyanikoglu A, Yakar F, Pinarbasi B, Demir
K, Ozdil S, Besisik F, Kaymakoglu S, Boztas G, Cuhadaroglu C, Mungan Z.
Effect of proton pump
inhibitor (PPI) treatment in obstructive sleep apnea syndrome: an
esophageal impedance-pHmetry study. Hepatogastroenterology.2011; 58(110-111):1566-73. doi: 10.5754/hge10465.
17. Rodrigues M.M., Dibbern R.S., Santos V.J. et al. (2014) Influence of
obesity on the correlation between laryngopharyngeal reflux and
obstructive sleep apnea. Braz J Otorhinolaryngol . 80, 5–10
18. Erdem D, Yılmaz YF, Özcan M, Titiz A, Özlügedik S, Ünal A.
Correlation
of sleep-disordered breathing and laryngopharyngeal reflux: a
two-channel triple-sensor pHmetry catheter study. Eur Arch
Otorhinolaryngol . 2018; 275(10):2585-2592. doi:
10.1007/s00405-018-5107-0.
19. Wise SK, Wise JC, DelGaudio
JM.Gastroesophageal reflux and laryngopharyngeal reflux in
patients with sleep-disordered breathing. Otolaryngol Head Neck
Surg . 2006; 135(2):253-7. doi: 10.1016/j.otohns.2006.05.012.
20. Ing AJ, Ngu MC, Breslin AB. Obstructive sleep apnea and
gastroesophageal reflux. Am J Med. 2000; 108(Suppl. 4a), 120S–125S
21. Xavier SD, Eckley CA, Duprat AC, de Souza Fontes LH,
Navarro-Rodriguez T, Patrocínio J, Tridente D, Lorenzi-Filho G.
Temporal Association
Between Respiratory Events and Reflux in Patients With
Obstructive Sleep Apnea and Laryngopharyngeal Reflux. J Clin
Sleep Med . 2019; 15(10):1397-1402. doi: 10.5664/jcsm.7960.
22. Lee JS, Heo SJ, Kim JS, Ahn D, Sohn JH, Kim H.
Relationship between
the severity of laryngopharyngeal reflux and sleepapnea: using
drug-induced sleep endoscopy (DISE). Eur Arch Otorhinolaryngol .
2018; 275(1):219-224. doi: 10.1007/s00405-017-4812-4.
23. Esteller E, Modolell I, Segarra F et al. Gastroesophageal reflux and
obstructive sleep apnea syndrome. Acta Otorrinolaringol Esp. 2005; 56,
411–415.
24. Teramoto S, Kume H, Ouchi Y. Nocturnalgastroesophageal reflux:
symptom of obstructive sleep apnea syndrome in association with impaired
swallowing. Chest . 2002. 122, 2266–2267.
25. Kuribayashi S, Massey BT, Hafeezullah M, Perera L, Hussaini SQ,
Tatro L, Darling RJ, Franco R, Shaker R.
Upper esophageal
sphincter and gastroesophageal junction pressure changes act to prevent
gastroesophageal and esophagopharyngeal reflux during apneic episodes in
patients with obstructive sleep apnea. Chest . 2010;
137(4):769-76. doi: 10.1378/chest.09-0913.
26. Shepherd K, Ockelford J, Ganasan V, Holloway R, Hillman D, Eastwood
P. Temporal
Relationship Between Night-Time Gastroesophageal Reflux Events
and Arousals From Sleep. Am J Gastroenterol . 2020;
115(5):697-705. doi: 10.14309/ajg.0000000000000627.