Pathogenesis:
The core pathogenesis that describes COVID-19 infection as the virus
that targets the respiratory system with rigorous pneumonia, joint as by
means of the occurrence of ground-glass opacities, RNAaemia, along with
the cardiac injury that is cute in nature Shen, C et al (2020).
Considerably higher levels of the cytokines along with chemokines in
blood were eminent in the patients having COVID-19 infection and these
included as IL7 IL1RA, IL8, IL1-β, IL9 and IL10 basic, GMCSF, IP10,
GCSF, IFNγ, MIP1α, MCP1, PDGFB, MIP1β, TNFα, in addition to the VEGFA
Dong, L et al (2020). The severe cases those who were in intensive care
unit (ICU) also appeared with the elevated levels of the
pro-inflammatory cytokines as those of the, IL7, IL2, IL10, IP10, GCSF,
MCP1, MIP1α, as well as TNFα that are rational to endorse the severity
of the disease Sanders, J et al (2020). The pathogenesis which explains
the biological process or mechanism which leads to the disease state.
The Patients tainted through COVID-19 showed to have the elevated
numbers of the leukocyte as well as the anomalous findings of the
respiratory tract, furthermore augmented levels as of the
pro-inflammatory types of cytokines in the plasma Luo, P et al (2020).
Some of the COVID-19 patients reports give the conclusion as present
with fever with those of cough loutish breathing sounds in both the
lungs, along with the temperature of body as about 39.0 °C. The sputum
of the patient presented with the positive synchronized polymerase chain
reaction consequences so as to confirm the infection of COVID-19 Ren, J
et al (2020).The laboratory investigation showed the results with the
appearance leucopenia by means of the leukocyte counts of about
2.90 × 10^9 cells/L of which about seventy percent were the WBC type
neutrophils. Furthermore, the elevated level of the C-reactive protein
as with the value of about 16.16 mg/L which is exceeding the standard
range of this C-reactive protein(0–10 mg/L). Also the elevated ESR
(erythrocyte sedimentation rate) as well as the D-dimer was also
pragmatic Wan, S et al (2020).