3.1 Ang II regulated miR-26a expression both in vivo and in
vitro
MiR-26a expression was reduced in AngII-treated VSMCs dose- and
time-dependently as compared with the control (Fig. 1a, b), so AngII
negatively regulated the expression of miR-26a. In vivo, the relative
level of miR-26a was lower in the thoracic aorta and plasma of
AngII-treated mice than the control (Fig. 1c), which indicated Ang II
regulated miR-26a expression both in vivo and in vitro.