3.8 miR-26a inversely regulates the activation of Smad3
We transfected AngII-induced VSMCs with an miR-26a mimic, which showed
high‐transfection efficiency (Fig. 8a). Also, transfection of an miR-26a
mimic significantly decreased p-Smad3 protein expression (Fig. 8b).
Additionally, upregulation of miR-26a inhibited nuclear translocation of
p-Smad3 (Fig. 8c). These results implied that miR-26a can also inversely
inhibit Smad3 activation.