We report a novel Cultured Neuronal Network on a chip as a viable
alternative to current culture methods for the analysis of neuronal
network formation and evolution of the structural properties of the
network's graph . This innovative microfluidic chip fabricated from
Polydimethylsiloxane, vinyl, and glass offers worthy features such as
the posibility to develop and produce custom designs effortlessly, easy
handling and monitoring, culture medium renewal, and reducing the
exposure to contamination. Due to these benefits, longer survival of the
neuronal networks are observed in comparison to conventional methods. In
addition to the fast and cost-effective manufacturing of the chip, this
technology provides a significant step forward in the studies of
neuronal network development and many challening applications such as
drug testing of in vitro cell culture models .